Fig. 2. Association of BMI with CNAs of breast cancer-specific driver genes in patients from the METABRIC, ICGC, and ELBC cohorts.

a–c Forest plots showing the associations evaluated using Firth’s logistic regression with p value < 0.05 between BMI, either as a continuous variable or a categorical variable (overweight vs lean, and obese vs lean), and gene-level CNAs in patients with NST ER+/HER2− (a), NST ER−/HER2− (b), and ILC ER+/HER2− (c). Gene-level CNAs with less than 10 events detected in the respective cohorts were not evaluated. Color-coded boxes indicate point estimates of odds ratios, and whiskers indicate their corresponding 95% confidence intervals. All statistical tests were two-sided. p values shown were not corrected for multiple testing. Exact p values < 0.001 are specified in Supplementary Data 9–10.