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. 2023 Jul 21;14:4418. doi: 10.1038/s41467-023-39996-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a, e Frequencies of non-malignant cell types relative to the non-malignant cell pool for NST ER+/HER2- (a) and NST ER-/HER2- (e) lean and obese patients (NST ER+/HER2− lean, n = 6; obese, n = 4; NST ER−/HER2− lean, n = 8; obese, n = 2). Each data point represents the frequency of the corresponding cell type detected in an individual sample. In each boxplot, the box denotes the range from the 25th to the 75th percentile, the center line indicates the median value, and the whiskers specify the maxima and minima excluding outliers. b, f CellChat-derived outgoing and incoming interaction strength from and to cancer cells and non-malignant cells in NST ER+/HER2- (b) and NST ER-/HER2- (f) tumors from lean and obese patients. c, g Differential number of interactions in NST ER+/HER2- (c) and NST ER-/HER2- (g) tumors detected by CellChat between lean and obese. d, h Relative Information flow of signaling pathways in the intercellular communication network in NST ER+/HER2- (d) and NST ER-/HER2- (h) tumors from lean and obese patients. The relative information flow was estimated by the sum of CellChat-derived communication probability between all pairs of cell compartments in the network. Signaling pathways with non-zero information in at least one of the BMI categories are shown.