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. 2023 Jul 21;13:11802. doi: 10.1038/s41598-023-38830-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Metabolome comparisons of short chain fatty acids (SCFAs) after UC induction and Bin1 immunotherapy. Mice on different diets for 7 months were induced UC using 3% DSS. After 6 days, they were treated with Bin1 mAb. The fecal pellets collected after 7 days were cultured anaerobically for 3 days and the metabolome determined. Bin1 mAb treatment lowered the levels of acetic acid that is known to increase during UC. Bin1 mAb treatment increased the levels of butyric acid, isobutyric acid, isocaproic acid, isovaleric acid, propionic acid and valeric acid either in all the diets or some diets (**P < 0.01, ***P < 0.001, ****P < 0.0001 as determined by t test). All results are expressed as Mean ± SD; (n = 4 mice per treatment).