Fig. 6. Effect of KN-93 on the tumor growth of Y-MESO-9 cells in vivo.

Y-MESO-9 cells (BAP1^−/−, 1 × 10⁷ cells/mouse) were subcutaneously xenografted into SCID mice. After the tumor volume reached 100 mm³ (day 0), KN-93 (15 mg/kg body weight) or vehicle (PBS) was intraperitoneally administered on days 0, 4, 8,13, and 16 into xenografted mice. a A representative picture of tumor-bearing xenografted mice in each group is shown. b, c Line graphs show (b) the relative tumor volume and (c) the body weight of mice during the treatment with KN-93. The tumor volume is expressed relative to the tumor size at day 0, arbitrarily defined as 100%. Data are expressed as the mean ± SE (n = 4).). *p < 0.05. d Western blot analysis using cleaved caspase3 showing the efficacy of KN-93 in tumor.