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. 2023 Jul 21;6:766. doi: 10.1038/s42003-023-05105-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Top, diagram representing normal dental epithelial differentiation and enamel formation in mouse mandible. CL cervical loop, Sec secretory stage, Mat maturation stage, DE-SCs dental epithelial stem cells, SI stratum intermedium. Bottom, hair regeneration by hair follicles under hair cycling regulation of resting telogen (left) and growing anagen (right) in skin. b Hair growth on Med1 cKO incisors at 4 weeks of age (top) is compared to normal hair in skin (bottom). Arrows show the root of hairs. c Top, HE sections of tissues emphasizing the atypical cell cluster (yellow triangles) surrounding hair shafts (yellow arrow) found between dentin and bone in Med1 cKO incisor (3 month). Bottom, HE sections for hair follicles at anagen (bottom) and telogen (top) phases supporting hair growth and regeneration in the skin (orange arrows). Bars = 50 μm. For b, c, representative images are shown. The diagram depicting the mouse mandible (brown colored) was created with BioRender.com, as were the ones shown in Figs. 2a, 3a, c, and 4a and Supplementary Figs. 1a and 4a.