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. 2023 Jul 21;6:766. doi: 10.1038/s42003-023-05105-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Diagram depicting the anatomical locations tested in Ctrl and Med1 cKO incisors. CL, cervical loop; Sec, secretory stage; Mat, maturation stage. b Heatmap showing differential gene expressions for epidermal genes (left) and hair genes (right) in Med1 cKO incisors versus Ctrls at 4 weeks of age. For each gene, fold changes are compared to CL Ctrl; n = 3 for all samples and average values for each group are shown. c Top, diagram depicts sequential expression of epidermal genes (light blue) and hair genes (blue) as well as hair growth (purple) in Med1 cKO mice regarding the different anatomical locations on incisors (CL, Sec, and Mat) of Med1 cKO incisors. Bottom, pattern comparison to epidermal (orange, E15) and hair gene inductions (yellow, E18) during embryonic development of the skin.