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. 2023 Jul 21;6:766. doi: 10.1038/s42003-023-05105-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Top, Schematic representations of cell sources for dental and skin epithelia are shown. Bottom, heatmap showing shared enhancers (either TE or SE) between dental (CLH, CLT) and skin (epidermal keratinocytes (Epi), and transient amplifying (TAC) hair follicle keratinocytes (hair)) epithelia for epidermal and hair lineage related transcription factors that are upregulated in Med1 cKO. b ChIP-seq profiles (mm10 genome) around the Hr (hairless) locus in CLH and CLT from Med1 cKO (pink) and Ctrl (blue) mice, compared to epidermal cells (green) and hair TAC keratinocytes (light blue) from skin. Pre-existing enhancers in Ctrl (blue bar) develop into super-enhancers (pink bar) upon loss of Med1 cKO in CLT. c Enhancer distribution profiles; super-enhancers associated with hair lineage genes and exclusively found in Ctrl or Med1 cKO CLT tissues are noted by the name of neighboring gene (blue circles). d Heatmap depicting differential gene expression of hair lineage genes in Med1 cKO compared to Ctrl in CLT. e Correlation between gene expression and H3K27ac promoter occupancy (TSS ± 30 kb) in Med1 cKO vs Ctrl in CLT tissues for the hair lineage driving gene set (orange dots) compared to all the other genes (blue dots). FC fold change.