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. 2023 Jul 21;6:765. doi: 10.1038/s42003-023-05120-6

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Barchart showing the number of malignant cells across different samples. b Relative proportion of malignant cells resembling each normal cell type. Only samples with more than 50 malignant cells are shown. c Venn diagram showing the number of differentially accessible regions (DARs) while comparing malignant cells with cell states of monocyte, MEP, Act (active) HSPC, LT (long-term) HSPC and hybrid to malignant cells without any cell state assigned. Hybrid cell state means more than one cell state is assigned to one cell. d Enrichment analysis of transcription factors (TFs) within each AML cell state. TFs are ranked based on their enrichment significance level on x axis. Arrows mark functional terms discussed in the main text. e Heatmap showing top 20 enriched TFs per cell state, colored by enrichment significance, with columns labeled as TFs and rows labeled as cell states.