Fig. 3. AML cell state-specific chromatin accessibility-driven gene signatures and their functions.

a Heatmap showing DARs and their linked DEGs, with five DAR-linked DEGs in active HSPC (ActHSPC) shown along the heatmap. Fold changes are visualized as binarized values, with open (>0) and closed (<0) for DARs, and up (>0) and down (<0) for DEGs. Rows are split based on AML cell state-specific DARs. b Venn diagram showing overlaps among the three gene signature sets, with ActHSPC signature gene set excluded. Functional enrichment treeplot for the three AML cell state-specific gene signature sets are shown in (c–e), respectively.