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. 2023 Jul 21;6:765. doi: 10.1038/s42003-023-05120-6

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a UMAP showing the trajectories across all eight patients, colored by inferred pseudotime. b UMAP showing six distinct cellular trajectories. c Heatmap showing the percentage of each AML cell state mapped to each trajectory. d Genomic distributions of trajectory-related open-chromatin regions. e Regulatory landscape across six distinct trajectories. f Top-unique transcription factors enriched for each trajectory.