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. 2023 Jul 21;6:765. doi: 10.1038/s42003-023-05120-6

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a The continuum of AML cell state scores defined by differential chromatin accessibility via comparing to their normal counterparts. b Heatmap showing top 20 most enriched transcription factors for AML cell states of B cell and MEP. c Survival analysis using the Cancer Genome Atlas (TCGA) AML cohort. Patients commonly high in B cell- and monocytes-derived scores are combined to generate the differentiated group, while patients commonly high in HSPC- and MEP-derived scores are combined to yield early progenitor group. Independent validation on prognostic values of our cell state-specific features is shown on the right using Abbas Cohort.