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. 2023 Jul 21;13:11790. doi: 10.1038/s41598-023-35401-3

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Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Comparison between high and low risk groups. (A) Comparison of risk scores in MYCN status, age groups and INSS stages. (B) The Sankey diagram showed the distribution of chromosomal abnormalities in the two risk groups. (C) The heat map showed the levels of differential genes between the high and low risk groups. (D) TOP 10 hub genes identified by MCC algorithm. (E) The bar graph showed the results of GSVA enrichment. Purple represented the major pathways enriched to in the high-risk group and green represented the major pathways in the low-risk group. (F) The TOP 3 most significant GO enriched terms in the high-risk and low-risk groups. (G) The TOP 3 most significant KEGG enriched pathways in the high-risk and low-risk groups.