Fig. 2. The effects of fat, fructose and glucose intake on the glycaemic status of mice.

(See Supplementary Data 3 for statistics). Source data are provided as a Source Data file. a, b. Response surfaces showing the relationship between the intake of fructose-, glucose- and fat-derived energy (kJ per mouse per day) and insulin tolerance (AUC) at weeks 15–16 (a) and the product of fasting blood glucose and fasting blood insulin concentrations (mmol/l × ng/ml) at weeks 12–14 (b). Increasing values of the AUC for the insulin tolerance test (ITT) indicate decreasing insulin sensitivity. c Relationship between fat mass (g) and the product of fasting blood glucose and fasting blood insulin concentrations (mmol/l × ng/ml) at weeks 12–14 (n = 193 mice). R² and p-value (for the regression slope, P = 2.229 × 10⁻²⁷) for linear regression of data are shown. d, e Response surfaces showing the relationship between the intake of fructose-, glucose- and fat-derived energy (kJ per mouse per day) and the total AUC of the glucose tolerance test (GTT) at weeks 12–14 (d) and the peak blood insulin (ng/ml) at weeks 12–14 (e).