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. 2023 Jul 21;9:75. doi: 10.1038/s41421-023-00582-8

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Individuals were recruited from the CNSR-III and underwent a series of standard diagnostic procedures according to the WHO criteria, and acute ischemic stroke was confirmed by MRI or brain CT. An electronic data capture (EDC) system was developed and used for data collection. Clinical phenotypes were extracted from EDC, medical records during hospitalization, biomarker measurement from biological samples, and death registry from the Chinese Center for Disease Control and Prevention (CDC). Individuals were followed up at 3 months, 6 months, and 1–5 years annually. Blood and urine samples were collected in face-to-face visits (baseline and follow-ups), and were stored in the Beijing Tiantan hospital. Omics screening is performed on the blood of the individuals. The number of high-quality genetic variants identified from the WGS is shown. Figure created with BioRender.com.