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. 2023 Jul 21;14(7):453. doi: 10.1038/s41419-023-05934-6

Fig. 4. Effect of H-MW-HA on oral mucositis scores in 5-FU treated mice.

Fig. 4

Oral mucositis (OM) was scored on a six-point scale as described in methods. A Representative photographs represent oral mucosa of the mice showing diffuse erythema on the anterodorsal surface of the tongue in treated mice after TB staining showing the epithelium ulceration (in blue) at the dorsal surface of the tongue. Yellow arrows show areas of erythema, erosion, and ulceration. B Comparative mucositis scores. Data are the mean ± SEM. *p < 0.01 versus control (A) and H-MW-HA (B) groups; **p < 0.01 versus control (A), H-MW-HA (B), and H-MW-HA + 5-FU (D) groups; #p < 0.01 versus 5-FU group; ##p < 0.01 versus control (A), H-MW-HA (B), and 5-FU (C) groups (Tukey’s post hoc test). (C) Mean value of the total score of oral mucositis between day-0 and day-19 for each group. Data are the mean ± SEM. *p = 0.0191; ***p < 0.0001 (Tukey’s post hoc test).