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. 2023 Jul 21;14(7):453. doi: 10.1038/s41419-023-05934-6

Fig. 9. Effect of H-MW-HA on increased IL-6, KC, and IL-13 expression induced by 5-fluorouracil (5-FU), and on superoxide dismutase (SOD) enzyme activity in 5-FU treated mice.

Fig. 9

Mice received 5-FU Intravenously (IV) with or without daily treatment of H-MW-HA (0.01%w/v) in the drinking water as described in the text. Animals were sacrificed at days 14, 16, and 19, and Blood samples were obtained. The expression of pro-Inflammatory cytokine protein levels, A–C IL-6, D–F CXCL1/KC, and G–I IL-13, was determined in serum at days 14, 16, and 19. SOD activity was measured in serum. J SOD activity at days 14, 16, and 19. K Total SOD activity between day-14 and day-19. Data are expressed as mean ± SD. *p < 0.05. **p < 0.005. ***p < 0.0001.