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. 2023 Jul 21;6:760. doi: 10.1038/s42003-023-05124-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a The significantly related ligand-receptor interactions of mostly communicated cell types. b Highly communicated ligand-receptor interactions between fibroblasts and tumor cells. c t-SNE plot shows the expressions of active tumor receptors including ITGAV, ITGB8, SDC1, SDC4, and CD44. d The upper panel shows the Kaplan-Meier (KM) overall survival curves for TCGA GBM patients, which are stratified by the median expression of the active tumor receptors. The lower panel shows the KM overall survival curves for GBM patients, which are stratified by the median expression of the active tumor receptors considering tumor purity. The y-axis represents the probability of overall survival, and the x-axis is time in days. e The upper panel shows the Kaplan-Meier (KM) progression-free survival (PFS) curves for GBM patients, which are stratified by the median expression of the active tumor receptors. The lower panel shows the KM PFS curves for GBM patients, which are stratified by the median expression of the active tumor receptors considering tumor purity. The y-axis represents the probability of PFS, and the x-axis is time in days.