Table 1.
Patient and sample characteristics.
| Characteristics | Samples | ||||
|---|---|---|---|---|---|
| BRBMET2 | BRBMET3 | BRBMET 87 | LUBMET7 | LUBMET1 | |
| Patient | |||||
| Age | 41 | 55 | 56 | 63 | 46 |
| Gender | F | F | F | F | F |
| Race, n (%) | B | W | W | W | W |
| Pathology | |||||
| Tissue Type | Tumor | Tumor | Tumor | Tumor | Adjacent Tumor |
| Primary Tumor | |||||
| Site | Breast | Breast | Breast | Lung | Lung |
| Subtype | Invasive ductal carcinoma, Nottingham grade 3 | Unknown* | Invasive ductal carcinoma with micropapillary features, Nottingham grade 3 | Not sampled | Adenocarcinoma |
| Molecular Feature | ER negative, PR negative, HER2 negative by IHC | ER negative, PR negative, HER2 negative* | ER positive (2%; weak intensity), PR positive (5%; strong intensity), HER2 amplification by FISH | Not sampled | Negative for rearrangements of ALK and ROS1 by FISH; EGFR mutation negative |
| Brain Metastasis | |||||
| Site | Left occipital lobe | Cerebellum | Left cerebellum | Left frontal lobe | Cerebellum |
| Characteristics | ER negative, PR negative, HER2 IHC 2+; Amplification of Her2 detected by FISH | ER negative PR negative, HER2 negative by IHC | Micropapillary type; ER positive (2%; weak to intermediate intensity), PR negative, HER2 3+ by IHC | Not applicable | Poorly differentiated adenocarcinoma; ROS1 rearrangement positive by FISH; ALK FISH negative, EGFR mutation negative |
Samples from five patients diagnosed with brain metastasis of breast and lung origins are included. Fresh remnant tumor tissues are collected for single-cell RNA-sequencing.
ER estrogen receptor, PR progesterone receptor, HER2 human epidermal growth factor receptor 2, IHC immunohistochemistry, FISH fluorescence in situ hybridization.