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. 2023 Jul 21;14:4419. doi: 10.1038/s41467-023-40070-x

Fig. 6. Enrichment of guQTL variants in regulatory elements and transcription factor binding sites involved in V(D)J recombination.

Fig. 6

a, b Bar plots showing the fraction of guQTL SNVs (P value < 9e−6) that overlapped (a) ENCODE candidate cis-regulatory elements, and (b) ENCODE3 TFBS, compared to the overlap observed for the non-guQTL set of variants used in the guQTL analysis. Regulatory elements and TFBS for which statistically significant enrichments were observed are indicated by asterisks: One-side Fisher’s Exact Test; *P value < 0.05; **P value < 0.005; ***P value < 0.0005; ****P value < 0.00005.