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. 2023 Jul 21;14:4419. doi: 10.1038/s41467-023-40070-x

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a–c For each IGHV gene, the distribution of coding region allele-level genotypes among individuals partitioned by genotype at the lead guQTL for that gene was assessed (Fisher’s exact test). For the three genes with the lowest P values from this analysis (a; IGHV3-64, b; IGHV3-53 and c; IGHV3-66), IgM gene usage (boxplots) and the distributions (stacked bar plots) of the respective coding allele genotypes across individuals partitioned by guQTL genotype are provided. Boxplots display the median, 25th percentile, 75th percentile, and whiskers that extend up to 1.5 times the inter-quartile range (IQR) from the respective percentiles. Data points outside the whiskers are also plotted.