Figure 7.

The prediction of binding sites of protein pairs from CAPRI rounds 46 and 50 test systems by identifying the shape‐matched low‐entropy regions of hydration shells of individual proteins. The remaining protein complexes of the test system are illustrated in Figure S4 (Supporting Information). The CAPRI target IDs and the corresponding PDBIDs are labeled. The binding sites of the two proteins are highlighted by yellow dashed lines, and the low‐entropy hydration shell region is highlighted in cyan.