Fig. 5.

Comparative proteomic analyses between saliva and plasma revealed the heterologous signatures of each biofluid and further divarication of convalescent COVID-19 saliva. (A) Proteomics data were further analyzed to compare proteomic composition between saliva vs. plasma. The data obtained from healthy and convalescent COVID-19 participants were separately analyzed. (B) Differentially expressed proteins (Log2 fold changes>1, p < 0.05) in saliva and plasma, were depicted as in a relative abundance of five significantly up-regulated proteins. The 95% confidence intervals of group memberships and degree of variance were indicated as circle and percentages on the axes, respectively. (C&D) The heterologous proteomic profile between saliva and plasma was further analyzed using clustered heatmap for both healthy and convalescent COVID-19. Relative abundance was calculated based on the proportion of normalized reads and displayed as color gradients. A dendrogram was constructed based on hierarchical clustering of relative abundances and color-coded demographic information of each participant was added to show their association with each clade. Blue Roman numerals and arrows indicate subclades in COVID-19 saliva. The numbering was in crescent with the expression level of DE proteins.