Fig. 6.

Correlation analyses suggest that proteomic alterations in convalescent saliva are associated with antibody responses specific to the receptor binding site (RBD) of SARS-CoV-2. (A–C) A significant correlation (p < 0.05) between SARS-CoV-2 RBD specific immunoglobulins and convalescent COVID-19 salivary sub-clusters was depicted as simple linear regression models. The individual titer of immunoglobulin was plotted by subcluster numbers. The predicted regression line and deviations were depicted as solid and dotted lines, respectively. Functions and p-value of regression analyses were indicated next to the regression lines. (D–H) Three differentially expressed proteins responsible for the clustering were illustrated as simple regression models as described above.