Table 1.

Major components of senescent associated secretory phenotypes.

Categories	SASP
Cytokine	IL-1/6/7/8/11/13/15/33
Chemokine	IL-8(CXLC8), GRO-a/b/g (CXCL1/2/3), CXCL5/6/13, MCP-1/2/4, MIP-1a/3a, I-TAC, CCL1/2/11/16/20/25/26, LIF
Growth factor	Amphiregulin, Angiogenin, Epiregulin, Heregulin, EGF, bFGF, HGF, KGF (FGF7), VEGF, Angiogenin, SCF, SDF-1, PIGF, NGF, IGFBP-1/2/3/4/6/7, VEGF, TGF-β,
Other inflammatory factors	GM-CSF, G-CSF, IFN-1/γ, MIF
Receptors and Ligands	Leptin, CXCR2, ICAM-1/3, OPG, sTNFRI/II, TRAIL-R3, Fas, uPAR, IL6ST, EGF-R, SAA1, TNFRSF18, SERPINE1, PIGF, sTNFRI/II
Oxidative factors	Nitric Oxide, ROS, COX2
Extracellular matrix contents	MMP1/2/3/10/12/13/14, SERPINs, TIMP1/2, Collagen, Laminin, Fibronectin, tPA, uPA
Exosome contents	GDF15, STC1, MMP1