REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
anti-Kbhb	PTM Biolabs	Cat# PTM-1201RM
anti-H3K9bhb (mono)	PTM Biolabs	Cat# PTM-1250
anti-H3K9bhb (poly)	PTM Biolabs	Cat# PTM-1250RM
anti-H4K8bhb	PTM Biolabs	Cat# PTM-1253RM
anti-Kac	Cell Signaling Technology	Cat# 9814S; RRID: AB_10544700
Normal rabbit IgG	Cell Signaling Technology	Cat# 2749
Goat anti-Rabbit IgG HRP	Thermo Scientific	Cat# 31460
Rabbit TrueBlot®: Anti-Rabbit IgG HRP	ROCKLAND	Cat# 18-8816-31
Chemicals, peptides, and recombinant proteins
DL-β-Hydroxybutyric acid sodium salt (BHB)	Sigma-Aldrich	H6501
Sodium butyrate	Sigma-Aldrich	B5887
Trichostatin A (TSA)	Sigma-Aldrich	T8552
RIPA buffer	Thermo Scientific	89901
Protease inhibitor cocktail	Thermo Scientific	A32965
Dynabeads™ M-280 Sheep Anti-Rabbit IgG	Invitrogen	11203D
DMEM (Dulbecco’s Modified Eagle’s Medium)	Gibco	10569044
DPBS (Dulbecco’s Phosphate Buffered Saline)	Gibco	14190250
Antibiotic-Antimycotic (100X)	Gibco	15240062
Sequencing Grade Modified Trypsin	Promega	V5110
Critical commercial assays
DC Protein Assay	BioRad	5000116
Experimental models: Cell lines
HEK293T	N/A	N/A
iMEFs	ATCC	CRL-1503
Software and algorithms
Prism (v9.5.1.)	Graphpad	https://www.graphpad.com/
ProteinProspector (v 6.4.0)	Guan et al., 201134	https://sargent.ucsf.edu/prospector/mshome.htm
Raw data	This paper	https://doi.org/10.17632/ttbt8hfhw5.1