. 2023 Jul 4;9(7):e17876. doi: 10.1016/j.heliyon.2023.e17876

Table 4.

Effects of different levodopa/benserazide doses on the blood pressure of older patients with Parkinson's disease.

Value	Group	Time	Lying position	1-min Standing	3-min Standing
SBP	125 mg	T0:“off state”	138.88 ± 24.42	128.13 ± 15.62	124.13 ± 18.57
	125 mg	T1:Best “on state”	133.88 ± 17.02	124.88 ± 14.56	120.00 ± 12.74
	250 mg	T0: “off state”	134.77 ± 20.61	131.13 ± 25.13	136.26 ± 23.92
	250 mg	T1:Best “on state”	127.39 ± 13.87#	124.16 ± 20.73#	120.23 ± 19.91#
	375 mg	T0: “off state”	136.55 ± 18.6	131.45 ± 27.98	131.7 ± 23.41
	375 mg	T1:Best “on state”	119.75 ± 18.81#	116.30 ± 21.75#	110.7 ± 13.88*#
Comparison among groups	F,P		0.340,0.713	1.321,0.275	4.155,0.047
Comparison within groups	F,P		0.290,0.743	7.018,0.010	4.276,0.024
Interaction (group × time)	F,P		1.500,0.218	1.098,0.358	4.095,0.042
DBP	125 mg	T0: “off state”	78.25 ± 10.28	77.00 ± 6.82	75.63 ± 8.6
	125 mg	T1:Best “on state”	75.25 ± 12.26	74.63 ± 11.53	74.38 ± 10.62
	250 mg	T0: “off state”	74.94 ± 10.61	76.87 ± 12.88	77.71 ± 11.98
	250 mg	T1:Best “on state”	67.65 ± 10.29#	70.55 ± 13.08#	71.71 ± 11.66#
	375 mg	T0: “off state”	79.5 ± 10.73	79.75 ± 12.54	80.9 ± 11.26
	375 mg	T1:Best “on state”	72.85 ± 11.68#	72.15 ± 13.52#	72.2 ± 13.43#
Comparison among groups	F,P		0.660,0.550	1.321,0.275	0.212,0.810
Comparison within groups	F,P		1.843,0.073	4.176,0.024	4.095,0.042
Interaction (group × time)	F,P		0.187,0.832	1.098,0.358	0.660,0.550

Data are presented as means ± standard deviations and compared using repeated-measures ANOVA; statistically significant results (P < 0.05) are in bold.

The comparison between groups utilized the Least—Significant Difference test, * Comparison with the 250 mg group at the same time, P < 0.05; The intra-group comparison between two groups used the Bonferroni method, # Comparison with this group at T0, P < 0.05.

SBP, systolic blood pressure; DBP, diastolic blood pressure.