Table 6.
Risk factors analysis of orthostatic hypotension and levodopa-induced orthostatic hypotension in the levodopa challenge test.
| Characteristics | “Off state” OH (n = 19) |
Best “on state” OH (n = 25) |
||||||
|---|---|---|---|---|---|---|---|---|
| Univariable OR (95% CI) | P value | Multivariable OR (95% CI) | P value | Univariable OR (95% CI) | P value | Multivariable OR (95% CI) | P value | |
| Cognitive impairment | 10.64 (1.284,88.169) | 0.028 | 70.117 (3.262,1507.273) | 0.007 | −0.964 (0.298,3.118) | 0.952 | – | – |
| “Off- state” OH | – | – | – | – | 64.579 (6.835,610.116) | 0.000 | 0.087 (0.019,0.396) | 0.002 |
| Best “on-state” OH | – | – | – | – | – | – | – | – |
| History of Hypertension | 20.07 (0.955,421.766) | 0.049 | 7.777 (0.833,72.569) | 0.072 | 0.762 (0.250,2.319) | 0.632 | – | – |
| Urinary incontinence | 0.284 (0.067,1.200) | 0.087 | – | – | 0.121 (0.035,0.422) | 0.001 | 0.158 (0.038, 0.655) | 0.011 |
Univariate and multivariate logistic regression analyses were performed to identify risk factors associated with OH occurrence. OR, odds ratio; CI, confidence interval; OH, orthostatic hypotension; “off-state,” defined as the period when all anti-PD drugs were withdrawn for at least 12 h; best “on-state,” defined as the peak of anti-PD drug benefit in the morning. P-values with statistical significance (<0.05) are in bold.