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. 2023 Jun 28;26(7):107241. doi: 10.1016/j.isci.2023.107241

Figure 1.

Figure 1

KOR activation evokes BAT thermogenesis, hyperthermia, and tail vasodilation

(A) Quantitative thermal images of BAT, eye, and tail at 0, 50, 70, and 90 min after i.p. administration of 5 mg/kg U50, 488H (U50) in wild-type mice.

(B–D) Quantified data for eye, BAT, and tail temperatures after pretreatment with saline or 10 mg/kg naltrexone hydrochloride i.p., then 30 min later 5 mg/kg U50 (n = 10).

(E) Thermal images of eye, BAT, and tail at 0, 50, 70, and 90 min in Oprk1−/− animals after administration of 5 mg/kg U50 i.p.

(F–H) Quantified thermal imaging of eye, BAT, and tail in Oprk1−/− animals. All data are presented as mean ± SEM (n = 5).