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. 2023 Jun 28;26(7):107241. doi: 10.1016/j.isci.2023.107241

Figure 2.

Figure 2

KOR activation in the CNS evokes increased BAT thermogenesis and tail vasodilation

(A) Illustration of the testing paradigm using intracerebroventricular injection of saline (black) or 1 nmol of norBNI (red). 10 mg/kg naloxone methiodide (blue) were given i.p. 5 mg/kg U50 was injected i.p. 30 min after pretreatment.

(B) Histological section showing guide cannula placement to align inner cannula into the lateral ventricle.

(C) Example quantitative thermal image after administration of 5 mg/kg U50.

(D–F) Quantified thermal imaging of BAT, eye, and tail temperatures following injection of saline, 1 nmol of norBNI i.v.c., or 10 mg/kg naloxone methiodide i.p., followed by 5 mg/kg U50 i.p. 30 min later. Data are presented as mean ± SEM (n = 7).