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. 2023 Jun 28;26(7):107241. doi: 10.1016/j.isci.2023.107241

Figure 4.

Figure 4

Antagonism of beta-3 adrenergic receptors or genetic disruption of Ucp1 blocks KOR activation evoked BAT thermogenesis

(A–C) Analysis of quantitative thermal imaging for (A) BAT, (B) eye, and (C) tail temperatures of wild-type mice (n = 8) administered saline (black), saline with U50 5 mg/kg (red), and U50 with SR59230A 10 mg/kg (blue). Co-administration of β3-AR antagonist SR59230A with U50 dampened the increase of BAT and eye temperatures but not of tail temperatures.

(D–F) Analysis of quantitative thermal imaging for (A) BAT, (B) eye, and (C) tail temperatures of Ucp1−/− mice (n = 8) administered saline (black) and saline with U50 5 mg/kg (red). Loss of Ucp1 expression greatly attenuated increases in temperatures following U50 administration. All data are presented as mean ± SEM.