Table 2.
Endemic Control (n=162) versus Visceral Leishmaniasis (n=211) |
Asymptomatic (n=229) versus Visceral Leishmaniasis (n=211) |
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trait | estimate | statistic | p value | 95% confidence interval | fold change VL/EC | Abs(-Log2(FC)) | estimate | statistic | p value | 95% confidence interval | fold change VL/ASYMP | Abs(-Log2(FC)) |
H7N6F2E2L2 | −0.000333959 | 9332 | 5.61268E-14 | −4.234E-04, -2.028E-04 | 3.554172646 | 1.829513763 | −0.000324287 | 13062 | 8.25232E-17 | −4.276E-04, -2.361E-04 | 3.673516604 | 1.877161796 |
H3N4F1E0L0 | −0.015903486 | 6351 | 2.35371E-25 | −2.090E-02, -1.178E-02 | 3.087935911 | 1.62664281 | −0.015679955 | 9098 | 1.27851E-29 | −2.045E-02, -1.193E-02 | 2.957398989 | 1.564328894 |
H7N6F2E1L3 | −0.000472738 | 8316 | 1.87697E-17 | −6.031E-04, -3.851E-04 | 3.073914738 | 1.620077149 | −0.000469817 | 12060 | 1.09077E-19 | −5.862E-04, -3.449E-04 | 3.012191827 | 1.590813649 |
TA2FG0S0 | −0.017082789 | 7090 | 3.35885E-22 | −2.297E-02, -1.278E-02 | 2.72252068 | 1.444943007 | −0.017116755 | 9986 | 2.02866E-26 | −2.243E-02, -1.320E-02 | 2.676110612 | 1.420137748 |
H7N6F1E2L2 | −0.001436856 | 7132 | 4.99858E-22 | −1.802E-03, -1.126E-03 | 2.700436606 | 1.433192681 | −0.001372454 | 10635 | 3.35236E-24 | −1.706E-03, -1.093E-03 | 2.593353639 | 1.374818951 |
H7N6F1E1L3 | −0.001426651 | 8214 | 7.97244E-18 | −1.774E-03, -1.052E-03 | 2.066125802 | 1.046928099 | −0.001450392 | 11190 | 2.19409E-22 | −1.771E-03, -1.105E-03 | 2.091898575 | 1.064812905 |
H7N6F1E2L1 | −0.000421909 | 9718 | 9.14226E-13 | −5.142E-04, -3.191E-04 | 1.990612673 | 0.993212533 | −0.000358146 | 15363 | 4.08903E-11 | −4.825E-04, -2.742E-04 | 1.802276681 | 0.849820507 |
H7N6F2E1L2 | −0.000172145 | 9265 | 3.40983E-14 | −2.341E-04, -1.302E-04 | 1.957405156 | 0.968942405 | −0.000158469 | 12249 | 3.97476E-19 | −2.233E-04, -1.323E-04 | 1.997725162 | 0.998358117 |
H7N6F0E3L1 | −0.000673024 | 8675 | 3.53983E-16 | −8.466E-04, -5.143E-04 | 1.941695611 | 0.957317055 | −0.000584096 | 14155 | 6.03412E-14 | −7.331E-04, -4.074E-04 | 1.753956647 | 0.810613089 |
A4Fa | −0.018205959 | 10453 | 1.26988E-10 | −2.464E-02, -1.245E-02 | 1.883239859 | 0.913216761 | −0.01737756 | 15542 | 1.00307E-10 | −2.327E-02, -1.211E-02 | 1.788044586 | 0.838382711 |
CFa | −0.001064005 | 10753 | 8.24797E-10 | −1.475E-03, -7.443E-04 | 1.833556463 | 0.874644693 | −0.001161761 | 14094 | 4.24967E-14 | −1.535E-03, -8.426E-04 | 1.929596553 | 0.948299235 |
H7N6F1E1L2 | −0.000454353 | 10098 | 1.24685E-11 | −5.661E-04, -3.447E-04 | 1.563655363 | 0.644922571 | −0.000462898 | 13987 | 2.28621E-14 | −5.780E-04, -3.497E-04 | 1.588369357 | 0.667546434 |
A4FE | −0.034608714 | 9243 | 2.89249E-14 | −4.348E-02, -2.584E-02 | 1.553742606 | 0.635747526 | −0.02954874 | 14875 | 3.23709E-12 | −3.829E-02, -2.149E-02 | 1.446997936 | 0.533062864 |
H6N5F1E2L1 | −0.012928867 | 9994 | 6.18002E-12 | −1.670E-02, -9.239E-03 | 1.552912 | 0.634976077 | −0.010462571 | 16134 | 1.72029E-09 | −1.394E-02, -7.069E-03 | 1.396888031 | 0.482216385 |
TA4L | −0.009546709 | 9309 | 4.73232E-14 | −1.216E-02, -7.050E-03 | 1.53876715 | 0.621774936 | −0.009979695 | 12822 | 1.77467E-17 | −1.238E-02, -7.632E-03 | 1.564958253 | 0.646124172 |
H4N3F1E1L0 | −0.000378964 | 11514 | 6.56136E-08 | −5.618E-04, -2.450E-04 | 1.527360195 | 0.611040331 | −0.000485353 | 13326 | 4.31247E-16 | −6.383E-04, -3.369E-04 | 1.685274019 | 0.752983187 |
A3LF | −0.102216601 | 9905 | 3.36276E-12 | −1.325E-01, -7.291E-02 | 1.523287438 | 0.607188198 | −0.094563735 | 15419 | 5.42458E-11 | −1.223E-01, -6.702E-02 | 1.435787509 | 0.521842252 |
A4FS | −0.089443483 | 9074 | 8.05079E-15 | −1.119E-01, -6.699E-02 | 1.515877628 | 0.600153294 | −0.078844343 | 14357 | 1.89856E-13 | −1.001E-01, -5.843E-02 | 1.432390715 | 0.518425072 |
A1F | −0.046002454 | 10146 | 1.71808E-11 | −6.292E-02, -3.113E-02 | 1.492857151 | 0.578076123 | −0.05080502 | 12888 | 2.71679E-17 | −6.716E-02, -3.680E-02 | 1.554828183 | 0.636755164 |
A1SF | −0.046002454 | 10146 | 1.71808E-11 | −6.292E-02, -3.113E-02 | 1.492857151 | 0.578076123 | −0.05080502 | 12888 | 2.71679E-17 | −6.716E-02, -3.680E-02 | 1.554828183 | 0.636755164 |
A4FL | −0.05447357 | 9028 | 5.65809E-15 | −6.806E-02, -4.102E-02 | 1.492622973 | 0.577849796 | −0.04893763 | 14072 | 3.74302E-14 | −6.163E-02, -3.677E-02 | 1.423205939 | 0.509144436 |
A4F | −0.092475741 | 9329 | 5.48931E-14 | −1.166E-01, -6.867E-02 | 1.490692436 | 0.575982627 | −0.081174541 | 14760 | 1.7469E-12 | −1.039E-01, -5.891E-02 | 1.406459449 | 0.492067957 |
A4EF | −0.092388254 | 9409 | 9.90121E-14 | −1.167E-01, -6.843E-02 | 1.485022284 | 0.57048458 | −0.08123373 | 14841 | 2.6995E-12 | −1.043E-01, -5.862E-02 | 1.402145799 | 0.487636373 |
A4SF | −0.092388254 | 9409 | 9.90121E-14 | −1.167E-01, -6.843E-02 | 1.485022284 | 0.57048458 | −0.08123373 | 14841 | 2.6995E-12 | −1.043E-01, -5.862E-02 | 1.402145799 | 0.487636373 |
TA4E | −0.009191054 | 9717 | 9.07802E-13 | −1.186E-02, -6.718E-03 | 1.473756216 | 0.559497898 | −0.009721826 | 13251 | 2.70655E-16 | −1.218E-02, -7.379E-03 | 1.506474377 | 0.591176135 |
A1EF | −0.046093344 | 10268 | 3.84392E-11 | −6.311E-02, -3.102E-02 | 1.47132638 | 0.557117311 | −0.051674461 | 12894 | 2.82368E-17 | −6.819E-02, -3.755E-02 | 1.539486008 | 0.622448755 |
A1L0F | −0.046093344 | 10268 | 3.84392E-11 | −6.311E-02, -3.102E-02 | 1.47132638 | 0.557117311 | −0.051674461 | 12894 | 2.82368E-17 | −6.819E-02, -3.755E-02 | 1.539486008 | 0.622448755 |
TA4 | −0.009168512 | 9713 | 8.82546E-13 | −1.185E-02, -6.703E-03 | 1.468051514 | 0.553902593 | −0.009744171 | 13229 | 2.35947E-16 | −1.221E-02, -7.399E-03 | 1.502683148 | 0.587540838 |
CA4 | −0.009262472 | 9749 | 1.13708E-12 | −1.196E-02, -6.754E-03 | 1.46361774 | 0.549538808 | −0.009868302 | 13217 | 2.18905E-16 | −1.237E-02, -7.511E-03 | 1.500942456 | 0.585868667 |
A34F | −0.08328953 | 9992 | 6.09657E-12 | −1.072E-01, -5.900E-02 | 1.460387177 | 0.546350906 | −0.078418236 | 15204 | 1.81557E-11 | −1.003E-01, -5.532E-02 | 1.398499757 | 0.483880003 |
A3EF | −0.080237836 | 10179 | 2.13909E-11 | −1.039E-01, -5.616E-02 | 1.445343397 | 0.531412302 | −0.075921853 | 15477 | 7.2561E-11 | −9.788E-02, -5.321E-02 | 1.38661645 | 0.471568781 |
A3F | −0.080237836 | 10179 | 2.13909E-11 | −1.039E-01, -5.616E-02 | 1.445343397 | 0.531412302 | −0.075921853 | 15477 | 7.2561E-11 | −9.788E-02, -5.321E-02 | 1.38661645 | 0.471568781 |
A3SF | −0.080237836 | 10179 | 2.13909E-11 | −1.039E-01, -5.616E-02 | 1.445343397 | 0.531412302 | −0.075921853 | 15477 | 7.2561E-11 | −9.788E-02, -5.321E-02 | 1.38661645 | 0.471568781 |
H3N4F0E0L0 | −0.000158411 | 10870 | 1.67315E-09 | −2.208E-04, -8.045E-05 | 1.441911762 | 0.527982882 | −0.000173979 | 14105 | 4.5277E-14 | −2.302E-04, -1.375E-04 | 1.564080738 | 0.645314986 |
A4LF | −0.090054475 | 9988 | 5.93297E-12 | −1.163E-01, -6.493E-02 | 1.433148107 | 0.519187711 | −0.07783696 | 15762 | 2.94984E-10 | −1.021E-01, -5.383E-02 | 1.351347835 | 0.43439907 |
A2S0G | 0.140194851 | 30024 | 5.13958E-36 | 1.212E-01, 1.594E-01 | 0.756133937 | 0.403286287 | 0.116166115 | 39404 | 2.65068E-30 | 9.818E-02, 1.342E-01 | 0.790332459 | 0.339468434 |
A2FS0G | 0.136941696 | 29754 | 1.34452E-34 | 1.180E-01, 1.563E-01 | 0.755659732 | 0.404191349 | 0.113087239 | 38996 | 8.62464E-29 | 9.508E-02, 1.314E-01 | 0.790315386 | 0.339499599 |
H6N5F0E2L0 | 0.002231585 | 26763 | 7.23795E-21 | 1.808E-03, 2.657E-03 | 0.719189514 | 0.475556108 | 0.002374427 | 37922 | 5.29388E-25 | 1.968E-03, 2.798E-03 | 0.707015758 | 0.500185725 |
H5N4F0E1L0 | 0.023719036 | 27158 | 1.7924E-22 | 1.980E-02, 2.757E-02 | 0.710562245 | 0.49296706 | 0.018094108 | 36292 | 8.68547E-20 | 1.494E-02, 2.091E-02 | 0.783538872 | 0.351923245 |
H5N4F0E0L2 | 0.000602187 | 27757 | 4.98381E-25 | 5.061E-04, 6.894E-04 | 0.697065025 | 0.520634851 | 0.000433998 | 36382 | 4.6518E-20 | 3.595E-04, 5.386E-04 | 0.765562088 | 0.385408708 |
H6N5F0E1L1 | 0.003485357 | 28194 | 5.51408E-27 | 2.939E-03, 3.985E-03 | 0.679944779 | 0.55651051 | 0.003030007 | 37651 | 4.31926E-24 | 2.484E-03, 3.540E-03 | 0.703024141 | 0.508353864 |
A2Fa | 0.000244241 | 28121 | 1.18469E-26 | 1.841E-04, 2.385E-04 | 0.677663015 | 0.561360059 | 0.00019451 | 37712 | 2.70246E-24 | 1.355E-04, 2.072E-04 | 0.772706325 | 0.372007887 |
H5N4F2E0L0 | 0.000161745 | 27406 | 1.63237E-23 | 1.563E-04, 1.758E-04 | 0.670475145 | 0.576744244 | 0.000134029 | 36606 | 9.64265E-21 | 1.058E-04, 1.564E-04 | 0.774074214 | 0.369456204 |
H5N4F0E0L0 | 0.001038368 | 28415 | 5.28256E-28 | 8.589E-04, 1.185E-03 | 0.510165943 | 0.970961502 | 0.000723915 | 37191 | 1.38707E-22 | 6.036E-04, 8.483E-04 | 0.690880212 | 0.533492503 |
See also Table S3.