Figure 3.

HfCas13x.1/cr9 improves motor functions in an AS mouse model

(A) Body weight of female mice was measured biweekly over 18 weeks. (B) Body weight of male mice was measured biweekly over 18 weeks. (C) Dowel test data in 13-week-old female mice. (D and E) Beam walking assays in 14-week-old female mice. Time to traverse the beam (D) and the number of foot slips (E) are shown. (F) Accelerating rotarod test data in 15-week-old female mice. (G) Hindlimb clasping assays in 7-week-old male mice. (H) Dowel test data in 13-week-old male mice. N = 12 for WT + NT; n = 10 for AS + NT; n = 17 for AS + cr9 in female mice. N = 13 for WT + NT; n = 9 for AS + NT; n = 14 for AS + cr9 in male mice. Statistical significance was assessed by one-way ANOVA followed by the Holm-Sidak comparison test. ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001. ns, not significant.