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. 2023 Mar 3;31(7):2154–2168. doi: 10.1016/j.ymthe.2023.02.023

Figure 2.

Figure 2

CTLA-4 blockade induces pyroptosis in HNSCC

(A and B) The expression of GSDMD and GSDME in the 4MOSC1 cell line and 4MOSC2 cell line was evaluated using western blotting (left) and corresponding quantitative analyses (right). (C and D) The production of GSDMD-N and GSDME-N was evaluated using western blotting in the control group (n = 3) and anti-CTLA-4 group (n = 3) for 4MOSC1 and 4MOSC2 tumors (left) and corresponding quantitative analyses (right). (E) Experimental schedule for tumor inoculation and CTLA-4 blockade. (F) Tumor volume of 4MOSC1 tumor-bearing mouse with CTLA-4 blockade. Data, mean ± SEM. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001.