Figure 4.

Vir-ZM@TD mediates antitumor immune responses by Mn-dependent cGAS activation and mtDNA release

(A) Preparation procedures of Vir-ZM@TD. (B) Cytosolic mtDNA levels after different treatment as an indicator for Vir-ZM@TD-mediated neoantigen release. (C) cGAMP production in 4T1 cells after different treatment. (D) Flow cytometry analysis of DC maturation (CD80⁺/CD86⁺) and proliferation of CD8⁺ T cells in 4T1 tumors after various treatments. (E) Immunoblotting analysis of TFAM expression in 4T1 tumors after indicated treatments. (F) Tumor growth curves for assessing the antitumor efficacy of various treatments. Reproduced under the terms of the CC BY license.¹⁵⁷