Figure 5.

LNPs/cGAMP improve anti-tumor efficacy by activating the cGAS-STING signaling in major APC population to promote T cell-mediated immune responses

(A) Schematic illustration of LNP/cGAMP-mediated activation of immune responses in TME. (B and C) Scheme of LNPs/cGAMP administration and treatment-induced volume changes of B16F10 tumors on mouse models. (D–F) Treatment scheme for LNP/cGAMP-mediated immunotherapy (D) and flow cytometry-based evaluation of DC maturation from tumors and draining lymph node (E) and tumor-residing macrophage polarization (CD80⁺ M1, and CD163⁺ M2) (F). Reproduced under the terms of the CC BY license.¹⁷²