Figure 7.

PSD31 potently stimulates chemoimmunotherapy responses in murine tumor models

(A) Schematic depiction of PS3D1@DMXAA structure and its synthesis process. (B) Ifnb mRNA expression after treatment with PS3D1@DMXAA NPs and DMXAA in DC2.4 and bone marrow-derived DCs (BMDCs) in the dose-dependent curves. (C) Schematic illustration of the treatment procedures of PS3D1@DMXAA NPs. (D) Flow cytometric analysis of DC maturation (CD80⁺/CD86⁺ DCs of CD45⁺/CD11c⁺ DCs) in the tumor-draining lymph nodes and IFN-γ producing tumor-infiltrating CD8⁺ T cells after 14 days of treatment. (E) Size comparison of B16.F10 tumors after different treatments. Reproduced under the terms of the CC BY license.¹⁹⁵