Figure 8.

BSA-Man@Mn2+-Ft@Lap mediates potent anti-tumor immunity

(A) Scheme illustration of construction of BSA-Man@Mn2+-Ft@Lap and its activation in the TME to enhance anti-tumor immune response in poorly immunogenic solid tumors. (B) Flow cytometry analysis of the heterogeneous targeting ability of the nanoassembly against APC or tumor cells after its dissociation in TME. (C) BSA-Man@Mn2+-Ft@Lap administration suppressed distal tumors through eliciting systemic antitumor immunity. (D) The nanoassemblies significantly promoted DC maturation and activation of CD8⁺/IFNγ⁺ T cells in vivo. Reproduced under the terms of the CC BY license.²⁰⁰