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. 2023 Apr 3;31(7):1979–1993. doi: 10.1016/j.ymthe.2023.03.032

Figure 4.

Figure 4

A subset of anti-AAV9 mAbs cross-react with other capsid serotypes

(A) Immuno-dot blot of the twenty-one mAbs, obtained from three treated infants, against the indicated AAV serotypes arrayed as per the template to the left of the panel. Equivalent antigen loading was confirmed using the B1 mAb. (B) Cross-reactive mAbs identified by immune dot blot were tested for anti-capsid reactivity by ELISA (upper row) and neutralization in a functional transduction assay (lower row). The immune dot blot is representative of three replicates. Data are pooled from duplicate and triplicate independent experiments for the ELISA and neutralization assays, respectively. Error bars indicate SEM.