Figure 5.

Fab binding sites on the AAV9 capsid

Three-dimensional reconstruction maps of AAV9 (without Fab) and in complex with Fab1-7 from patients 1, 2, and 3. The maps are radially colored according to distance to the center of the capsid blue to red, as indicated by the scale at the top of the panel. The icosahedral 2-, 3-, and 5-fold axes and the 2/5-fold wall are indicated on the schematic and “AAV9 no Fab” capsid map, and Fab-binding sites are given above each map. The estimated resolutions, determined at a Fourier shell correlation (FSC) threshold value of 0.143, is shown below each map.