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. 2023 Apr 13;31(7):2028–2041. doi: 10.1016/j.ymthe.2023.04.005

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© 2023 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Montage showing retinal cross-sections from canine eyes from each treatment group from the highest to the lowest dose

(A) Dose group 4 (17-011 OD), (B) dose group 3 (17-007 OD), (C) dose group 2 (17-040 OD), and (D) dose group 1 (18-076 OS). (E) Untreated portion of a treated eye (17-011 OD). The first column is a color fundus image taken immediately after subretinal injection. The dotted line shows the plane of the histological section and the asterisk the region of the section imaged. The first IHC column is labeled for CNGB1 (in red) and shows a dosage effect. The next column shows CNGA1 labeling (in green) also showing a dosage effect. Note that CNGA1 expression is dependent on CNGB1 expression. The final column is the merge. Size bar, 25 μm.