Skip to main content
. 2023 Apr 13;31(7):2028–2041. doi: 10.1016/j.ymthe.2023.04.005

Figure 4.

Figure 4

Gene augmentation therapy reverses disease-related cGMP accumulation

(A) shows an untreated retinal area of a CNGB1 mutant dog (17-011 OD group 4). cGMP is in green with the insert showing a magnified view of the region in the white box. Note cGMP is detected in the inner and outer segment layers of the photoreceptors. (B) shows the same eye in a treated retinal region cGMP is green and CNGB1 red. Note the lack of accumulation of cGMP in the treated retinal region where CNGB1 labeling is present. Size bar, 25 μm.