Figure 5.

Gene augmentation rescue of rod function

(A) ERG dark-adapted luminance series from an untreated eye (17–042 OS 6 mo), an eye 6 months post injection (17-007 OD Gp3), and the same eye 12 months post injection. The red tracings indicate the ISCEV recommended ERG flash stimuli of 0.01, 3, and 10 cd‧s/m². (B) Rod 5-Hz flicker (0.025 cd‧s/m²) results in the same eyes as in (A). (C–E) The mean (+/− SEM) dark-adapted ERG amplitudes for the ISCEV flash stimuli of 0.01, 3, and 10 cd‧s/m² for the control eyes (Gp0) and the four dose groups (Gp1, Gp2, Gp3, Gp4). The 6-month post injection time point is in black, and the 12-month time point is in gray. Note that Gp1 was only maintained to 6 months post injection. There is no a-wave response at 0.01 cd‧/m². (F) The mean (+/− SEM) 5-Hz rod flicker amplitudes for the same groups as in (C)–(E).