Figure 7.

Structural preservation in treated eye

(A) Fundus photographs of Gp 3 (1E+12 Titer, 2E+11 Dose) dog 17-007 OD (right eye). The color fundus images show the injection bleb immediately after injection and then the fundus 1 year later. (B) B1. The cSLO images show infrared and autofluorescent imaging of the injected region. B2. A heatmap clearly shows the preservation of the treated retinal area, showing REC+ thickness. (C) REC+, ONL, IR, and TR thicknesses ratio of thickness in treated regions versus thickness in untreated regions at 12 months post injection for three doses/groups (mean ratio +/- SD). This shows preservation of the outer retina layers REC+ and ONL for all groups in the treated regions. (D) cSLO (left) and SD-OCT high-resolution retinal cross-section (right) images show the treated and untreated adjacent regions. The red arrow indicates the junction between treated and untreated regions. The two enlarged images above show high magnification of untreated and treated regions. Notice the thicker outer nuclear layer in the treated region and the improved definition of ELM, EZ, and IZ bands. TR, total retina; REC+, Receptor+; IR, inner retina; NFL, nerve fiber layer; GCL, ganglion cell layer; IPL, inner plexiform layer; INL, inner nuclear layer; OPL, outer plexiform layer; ONL, outer nuclear layer; ELM, external limiting membrane; EZ, ellipsoid zone; IZ, interdigitation zone.