Table 1.
List of the dogs and details of the injected dose, eye, and follow-up times
| Titer (vg/mL) | Total dose delivered (vg total) | Dog | Sex | Eye | Follow-up time points (months) | Time of euthanasia post injection (months) |
|---|---|---|---|---|---|---|
| Group 0–2 eyes untreated controls | ||||||
| Nothing | nothing | 17-038 | F | left | 6, 12 | 12 |
| Nothing | nothing | 17-042 | F | left | 6, 12 | 12 |
| Group 1–3 eyes aav5-rho-cngb1 injected | ||||||
| 1E+11 | 2E+10 | 17-041 | F | right | 6 | 6 |
| 1E+11 | 2E+10 | 17-040 | M | left | 6 | 6 |
| 1E+11 | 2E+10 | 18-076 | M | left | 6 | 9 |
| Group 2–5 eyes aav5-rho-cngb1 injected | ||||||
| 5E+11 | 1E+11 | 17-041 | F | left | 6 | 6 |
| 5E+11 | 1E+11 | 17-040 | M | right | 6 | 6 |
| 5E+11 | 1E+11 | 18-073 | F | right | 6, 12 | kept long term |
| 5E+11 | 1E+11 | 18-074 | M | left | 6, 12 | kept long term |
| 5E+11 | 1E+11 | 18-076 | M | right | 6 | 9 |
| Group 3–5 eyes aav5-rho-cngb1 injected | ||||||
| 1E+12 | 2E+11 | 17-010 | F | right | 6, 12 | 12 |
| 1E+12 | 2E+11 | 17-011 | M | left | 6, 12 | 12 |
| 1E+12 | 2E+11 | 17-007 | M | right | 6, 12 | 12 |
| 1E+12 | 2E+11 | 17-038 | F | right | 6, 12 | 12 |
| 1E+12 | 2E+11 | 17-042 | F | right | 6, 12 | 12 |
| Group 4–5 eyes aav5-rho-cngb1 injected | ||||||
| 5E+12 | 1E+12 | 17-010 | F | left | 6, 12 | 12 |
| 5E+12 | 1E+12 | 17-011 | M | right | 6, 12 | 12 |
| 5E+12 | 1E+12 | 17-007 | M | left | 6, 12 | 12 |
| 5E+12 | 1E+12 | 18-073 | F | left | 6, 12 | kept long term |
| 5E+12 | 1E+12 | 18-074 | M | right | 6, 12 | kept long term |