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Structures of hTERT promoter-driven oncolytic adenovirus, OBP-301
(A and B) OBP-301 (Suratadenoturev) is a recently developed attenuated type 5 adenovirus (Ad5) in which a promoter of hTERT is used to increase the expression of adenovirus early region 1A (E1A) and early region 1B (E1B), which are associated with an internal ribosome entry site (IRES) sequence. hTERT, human telomerase reverse transcriptase; ITR, inverted terminal repeat.
