Figure 5.

Representative computed tomography results of tumors in three patients who had target tumor responses (RECIST criteria)

(A) The white circle indicates tumor regions before and after the administration of OBP-301. Blue arrow: target lesion. Red arrow: bystander effect. (B) Histological assessment of the circled area of patient no. 501 after OBP-301 injection. H&E staining showed that necrotic cell death was found along the viral injection area. OBP-301 promoted apoptotic cell death. H&E, hematoxylin and eosin; MT, Masson trichrome; Ad5, adenovirus type 5; Tunnel, terminal deoxynucleotidyl transferase dUTP nick end labeling.