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. 2023 Mar 21;31(7):2089–2104. doi: 10.1016/j.ymthe.2023.03.020

Figure 2.

Figure 2

Parameters affecting CAR efficacy

To determine the effect of the binder biophysical properties to the CAR efficacy, we calculated two-dimensional correlation plots of Ig domain (A), association rate (Ka) (B), dissociation rate (Kd) (C), affinity (KD) (D), binder stability (°C) (E), and aggregation (F) to the CAR efficacy. For the CAR efficacy, we introduced the cytotoxicity of the novel aCD22 binders against SupT1 CD22High (blue) or CD22Mid (red) in 1:4 ratio. The r values represent Pearson correlation coefficients (n = 8–12).