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. 2023 Apr 17;31(7):2105–2119. doi: 10.1016/j.ymthe.2023.04.008

Figure 5.

Figure 5

The effects of CXCR2 and CCR2 blockade on MDSC mobilization and T cell infiltration induced by HFRT

(A) Representative flow plots of MDSCs in MC38 tumors on day 7 after radiation initiation (gated on CD45+ cells). (B and C) Bar plot showing fractions of CD45+ cells and MDSCs in the tumor, blood, spleen, and bone marrow of mice bearing MC38 tumors. (D) Representative flow plots of CD3+(gated on live cells), CD4+, and CD8+ T cells (gated on CD45+ cells) in MC38 tumors. (E) Bar plots showing fractions of CD3+, CD4+, and CD8+ T cells (percentage of all live cells) in MC38 tumors. (F) Representative flow plots of MDSCs in CCR2KO or wild-type (C57BL/6) mice tumors (gated on CD45+ cells). (G and H) Bar plot showing fractions of CD45+ cells and MDSCs in the tumor, blood, spleen, and bone marrow of CCR2KO mice or wild-type mice. (I) Representative flow plots of CD3+ T cells (gated on live cells), CD4+ T cells, and CD8+ T cells (gated on CD45+ cells) in CCR2KO or wild-type (C57 BL/6) mice tumors. (J) Bar plots showing fractions of T cells (percentage of all live cells) in CCR2KO or wild type (C57BL/6) mice. Results are presented as mean ± SEM. ∗p < 0.05 and ∗∗p < 0.01; NS, p > 0.05 (unpaired Student’s t test).