Table 1.
Characteristics of the included studies.
| Autor | Year | Country | Type of delivery | TXA Dose | Control | Patients TXA (n) | Patients Control (n) | Type of anesthesia (cesarean) |
|---|---|---|---|---|---|---|---|---|
| Gungorduk et al. | 2011 | Turkey | Cesarean | 1g, 10 min before incision | 30 mL glucose 5% | 330 | 330 | Non described |
| Movafegh et al. | 2011 | Iran | Cesarean | 10 mg.kg−1, 20 min before anesthesia | Saline IV | 50 | 50 | Spinal |
| Sentürk et al. | 2012 | Turkey | Cesarean | 1 g, 5 min before incision | Dextrose 5% | 101 | 122 | Spinal |
| Gungorduk et al. | 2013 | Turkey | Vaginal | 1 g, for 5 min after extracting the anterior shoulder | 30 mL glucose 5% | 220 | 219 | ‒ |
| Xu et al. | 2013 | China | Cesarean | 10 mg.kg−1 + 200 mL saline | 200 mL saline | 88 | 86 | Spinal |
| Goswami et al. A | 2013 | India | Cesarean | 10 mg.kg−1 + 20 mL dextrose 5% | 5 mL DW + 20 mL dextrose 5% | 30 | 30 | Spinal |
| Goswami et al. B | 2013 | India | Cesarean | 15 mg.kg−1 + 20 mL dextrose 5% | 5 mL DW + 20 mL de dextrose 5% | 30 | 30 | Spinal |
| Shahid et al. | 2013 | Pakistan | Cesarean | 1g + 20 mL glucose 5% | 10 mL DW + 20 mL glucose 5% | 38 | 36 | Spinal |
| Ghosh et al. | 2014 | India | Cesarean | 1g | 10 mL DW | 70 | 70 | Spinal |
| Maged et al. | 2015 | Egypt | Cesarean | 1g | 30 mL glucose 5% | 100 | 100 | Non described |
| Mirghafourvand et al. | 2015 | Iran | Vaginal | 1g, after extracting the anterior shoulder | DW | 60 | 60 | ‒ |
| Sujata et al.a | 2016 | India | Cesarean | 10 mg.kg−1 | Saline IV | 30 | 30 | Non described |
| Ismail et al. | 2017 | Egypt | Vaginal | 1g, soon after delivery | 30 mL glucose 5% | 100 | 100 | ‒ |
| Abbas et al. | 2018 | Egypt | Cesarean | 1g before incision | Saline IV | 31 | 31 | General |
| Sentilhes et al. | 2018 | France | Vaginal | 1g, 2 min after delivery | Saline IV | 1931 | 1927 | ‒ |
| Sujita et al. | 2018 | Thailand | Vaginal | 1g + 20 mL saline (30 mL total) | 30 mL saline | 72 | 69 | ‒ |
| Millani et al. | 2019 | Iran | Cesarean | 1g + 20 mL of DW, 15 min before incision | Glucose 5% 10 mL + 20 mL DW | 30 | 30 | Spinal |
| Shah et al. | 2019 | Nepal | Cesarean | 1g | 10 mL saline | 80 | 80 | Non described |
a
This trial was not included in the meta-analysis because lack of data; IV, Intravenous; DW, Distilled Water; A and B, In Goswami et al. the analysis was divided into two groups because two different doses of TXA were used (10 mg.kg−1 and 15 mg.kg−1).