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. Author manuscript; available in PMC: 2023 Sep 1.
Published in final edited form as: Nat Chem Biol. 2023 Feb 13;19(3):378–388. doi: 10.1038/s41589-022-01253-7

Extended Data Fig. 1. Characterization of sgTMEM164 786-O cells.

Extended Data Fig. 1

a, b, Confirmation of genetic alterations in 786-O cells at sgRNA sites targeted with (a) sgTMEM164-1 and (b) sgTMEM164-2 by next-generation sequencing analysis. c, d, Genetic deletion of TMEM164 in 786-O cells results in reduced sensitivity to ferroptosis induced by the GPX4 inhibitors ML210 (c) and RSL3 (d) measured at 24 h post-treatment with GPX4 inhibitors. Data represent mean values ± S.E.M. from two independent experiments.